What Is Detralex?
Detralex contains a micronized purified flavonoid fraction (MPFF) composed of 450 mg diosmin and 50 mg hesperidin, derived from citrus peels. It’s classified under angioprotectors/phlebotonics and effectively reduces inflammation and improves venous tone and microcirculation .
Indications
Chronic venous insufficiency: symptoms like leg heaviness, swelling, pain, cramps, and trophic changes .
Hemorrhoidal episodes: both acute and chronic stages benefit from pharmacotherapy .
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How It Works
Increases venous tone, reduces vein distensibility and capillary permeability
Improves lymphatic drainage and microcirculation
Exhibits anti-inflammatory effects via reduction of leukocyte adhesion and prostaglandin inhibition .
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Dosage
For venous insufficiency:
2 tablets/day, one at noon and one in the evening with meals .
For acute hemorrhoids:
6 tablets/day for the first 4 days, then 4 tablets/day for the next 3 days .
Maintenance may continue at 2 tablets/day based on physician guidance .
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Safety & Side Effects
Generally well tolerated. Common side effects (<10%) include gastrointestinal disturbances (diarrhea, nausea, abdominal pain) and rarely skin reactions (rash, urticaria). Headache, dizziness, fatigue are uncommon .
Contraindications: hypersensitivity to diosmin/hesperidin or excipients. Caution during breastfeeding .
No known interactions with alcohol or other medications, though concurrent use of compression therapy and lifestyle habits enhances effectiveness .
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Clinical & User Evidence
Cochrane reviews & clinical guidelines support diosmin/MPFF in improving venous swelling and pain; moderate evidence also supports hemorrhoid relief .
Reddit user experience echoes effectiveness in early hemorrhoids:
> “Detralex / Daflon works really good and fast … literally the best treatment for hemorrhoids” .
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Practical Tips
Take during meals to minimize gastrointestinal upset .
Combine with compression stockings, physical activity, weight control, and avoiding prolonged standing/sitting .
For hemorrhoid flare-ups, follow the 7-day intensive dosing; consult a proctologist if symptoms persist beyond 15 days .
