What Is Brufen 400 mg?
Brufen 400 mg is a film-coated tablet containing 400 mg of ibuprofen, a potent non‑steroidal anti-inflammatory drug (NSAID). It is widely used for its analgesic, antipyretic, and anti-inflammatory effects .
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Indications
Brufen 400 mg is indicated for:
Arthritic conditions (rheumatoid and osteoarthritis), bursitis, tendonitis, back pain
Mild to moderate pain: headache, migraine, dental pain, dysmenorrhea
Fever reduction
Soft-tissue injuries, sprains, strains
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Dosage & Administration
Adults & Adolescents (≥12 years)
Regular dosing: 1200–1800 mg/day in divided doses (typically 300–600 mg TID)
Higher needs (e.g., arthritis flare-ups): up to 2400 mg/day under medical supervision
Acute pain/fever: 400 mg every 4–6 hours; max 1200 mg/day OTC or up to 3200 mg/day prescription
Swallow tablets whole with water, preferably after food to reduce gastrointestinal side effects .
Children Under 12
Not recommended in this form. Use pediatric formulations (liquid or lower-dose tablets) .
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How It Works
Ibuprofen works by inhibiting COX‑1 and COX‑2 enzymes, reducing prostaglandin production—resulting in decreased pain, fever, and inflammation .
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Safety & Precautions
Contraindications: NSAID allergy, active gastrointestinal bleeding or ulcers, recent CABG surgery, severe heart/liver/kidney disease, NSAID-induced asthma
Side effects: GI upset, nausea, headache, dizziness, rare serious effects—gastric bleeding, renal impairment, cardiovascular risks at high doses
At‑risk groups: elderly, dehydrated, on anticoagulants, hypertension, or heart disease—use lowest effective dose
Pregnant women (especially late pregnancy), breastfeeding individuals, or children under medical supervision should consult a doctor before use .
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Practical Tips
Take with food or milk to protect the stomach
Drink plenty of fluids, especially if on long-term therapy
Avoid mixing with other NSAIDs or alcohol to lower the risk of side effects
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Conclusion
Brufen 400 mg (30 tablets) offers comprehensive, fast‑acting relief for a variety of pain, inflammation, and fever symptoms. With responsible use—sticking to recommended doses and precautions—it remains a trusted OTC and prescription-level NSAID.
